Article
Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.
Nature communications - 7 Jun 2016
Bohannon Caitlin, Powers Ryan, Satyabhama Lakshmipriyadarshini, Cui Ang, Tipton Christopher, Michaeli Miri, Skountzou Ioanna, Mittler Robert S, Kleinstein Steven H, Mehr Ramit, Lee Frances Eun-Yun, Sanz Ignacio, Jacob Joshy
Abstract excerpt
Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells-with T-cell help-undergo affinity maturation within germinal centres and persist as long-lived IgG plasma cells in the bone marrow. Here we show that antigen-specific, induced IgM plasma cells also persist for a lifetime. Unlike long-lived IgG plasma cells, which develop in germinal...
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