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Mini‐review Activation‐induced cytidine deaminase: a dual role in class‐switch recombination and somatic hypermutation

27 Jun 2003

Abstract excerpt

Maturation of the antibody repertoire is mediated by two different mechanisms: class-switch recombination (CSR) and somatic hypermutation (SHM). These two processes are T cell dependent and occur in the germinal centers of secondary lymphoid organs. CSR leads to the production of antibodies of different isotypes whereas SHM leads to the selection of B cells expressing a BCR with high affinity for antigen. The...

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PMID: 12884279
DOI: 10.1002/eji.200324133

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