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Article

Somatic hypermutation shapes the antibody repertoire of memory B cells in humans.

The Journal of experimental medicine - 6 Aug 2001

Meffre E, Catalan N, Seltz F, Fischer A, Nussenzweig M C, Durandy A

Abstract excerpt

High-affinity antibodies produced by memory B cells differ from antibodies produced in naive B cells in two respects. First, many of these antibodies show somatic hypermutation, and second, the repertoire of antibodies expressed in memory responses is highly selected. To determine whether somatic hypermutation is responsible for the shift in the antibody repertoire during affinity maturation, we analyzed the...

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Identifiers

PMID: 11489956
DOI: 10.1084/jem.194.3.375
PMCID: PMC2193472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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