Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.

Abstract excerpt

Hyper-immunoglobulin M (IgM) syndromes are primary immunodeficiencies characterized by normal or elevated serum IgM levels with the absence of other isotypes, pinpointing to a defect in the Ig class switch recombination (CSR). The delineation of hyper-IgM syndromes made it possible to better define the mechanisms underlying the two major events of antibody maturation in humans, CSR and introduction of somatic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to AICDA (Activation-Induced Cytidine Deaminase)
• Share to Cytidine Deaminase