Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of CYP2C9 and VKORC1 Gene Variants on Warfarin Response in Patients with Continuous-Flow Left Ventricular Assist Devices.

ASAIO journal (American Society for Artificial Internal Organs : 1992) - 1 Jan 2000

Topkara Veli K, Knotts Robert J, Jennings Douglas L, Garan A Reshad, Levin Allison P, Breskin Alexander, Castagna Francesco, Cagliostro Barbara, Yuzefpolskaya Melana, Takeda Koji, Takayama Hiroo, Uriel Nir, Mancini Donna M, Eisenberger Andrew, Naka Yoshifumi, Colombo Paolo C, Jorde Ulrich P

Abstract excerpt

Bleeding and thrombotic complications continue to plague continuous-flow left ventricular assist device (CF-LVAD) therapy in patients with end-stage heart failure. Warfarin genotyping information can be incorporated into decision making for initial dosing as recommended by the Food and Drug Administration; however, clinical utility of this data in the CF-LVAD population has not been well studied. Genotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Blood Coagulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Hemorrhage

Share to International Normalized Ratio

Share to Polymorphism, Genetic

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 27258224
DOI: 10.1097/MAT.0000000000000390

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of CYP2C9 and VKORC1 Gene Variants on Warfarin Response in Patients with Continuous-Flow Left Ventricular Assist Devices.PMID 27258224Read ↗

Preliminary Study on the Relationship between VKORC1 Gene Polymorphism and Warfarin Anticoagulant Therapy in Chinese patients with Continuous-Flow Left Ventricular Assist DevicesSemantic proximity Read ↗

Effects of vitamin K epoxide reductase complex 1 gene polymorphisms on warfarin control in Japanese patients with left ventricular assist devices (LVAD).Semantic proximity Read ↗

Genetic variations of phenprocoumon metabolism in patients with ventricular assist devices.Semantic proximity Read ↗

CYP2C9 Polymorphism and Unstable Anticoagulation with Warfarin in Patients Within the First 3 Months Following Heart Valve Replacement.Semantic proximity Read ↗

Genotype-Guided Warfarin Dosing in Patients With Mechanical Valves: A Randomized Controlled Trial.Semantic proximity Read ↗

Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery.Semantic proximity Read ↗

Genotype-guided warfarin dosing may benefit patients with mechanical aortic valve replacements: randomized controlled study.Semantic proximity Read ↗

Prevalence of Warfarin Genotype Polymorphisms in Patients with Mechanical Circulatory Support.Semantic proximity Read ↗

Effect of CYP2C9 and VKORC1 genotypes on early-phase and steady-state warfarin dosing in Korean patients with mechanical heart valve replacement.Semantic proximity Read ↗

Genetic influence on bleeding and over-anticoagulation risk in patients undergoing warfarin treatment after heart valve replacements.Semantic proximity Read ↗

A clinical study of genetic testing to guide the dosing of warfarin after heart valve replacement.Semantic proximity Read ↗

Pharmacist-Led Genotype-Guided Warfarin Therapy in Valve Replacement: An Observation Cohort Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.