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Article

Genotype-Guided Warfarin Dosing in Patients With Mechanical Valves: A Randomized Controlled Trial.

The Annals of thoracic surgery - 1 Dec 2018

Xu Zhe, Zhang Shu-Yu, Huang Min, Hu Rong, Li Jia-Li, Cen Han-Jin, Wang Zhi-Ping, Ou Jing-Song, Yin Sheng-Li, Xu Ying-Qi, Wu Zhong-Kai, Zhang Xi

Abstract excerpt

BACKGROUND: The clinical utility of genotype-guided warfarin dosing remains controversial. The objective of this trial was to evaluate the efficacy and safety of genotype-guided warfarin dosing in East Asians. METHODS: A double-blind, randomized control trial was performed to compare a genotype-guided dosing algorithm (CYP2C9, VKORC1, and CYP4F2) with a clinical-guided one in the initiation treatment for patients...

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Identifiers

PMID: 30205115
DOI: 10.1016/j.athoracsur.2018.07.026

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