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Article

Genetic variations of phenprocoumon metabolism in patients with ventricular assist devices.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Aug 2016

Brehm Kerstin, Krumnau Oliver, Heilmann Claudia, Beyersdorf Friedhelm

Abstract excerpt

OBJECTIVES: Anticoagulation in patients with ventricular assist device (VAD) support is crucial and to date, no alternative to vitamin K antagonists (VKAs) can be safely used. Genetic variances of cytochrome p450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC) have been recently connected with variation of VKA maintenance as well as loading doses. In this retrospective study, we assessed the incidence of...

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Source

Identifiers

PMID: 26984978
DOI: 10.1093/ejcts/ezw060

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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