Article
CYP2C9 Polymorphism and Unstable Anticoagulation with Warfarin in Patients Within the First 3 Months Following Heart Valve Replacement.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jan 2000
Wypasek Ewa, Cieśla Marek, Suder Bogdan, Janik Łukasz, Sadowski Jerzy, Undas Anetta
Abstract excerpt
BACKGROUND: Warfarin dose requirements are partly determined by common single nucleotide polymorphisms in VKORC1 and CYP2C9 genes. OBJECTIVES: The aim of this study was to investigate how the presence of allelic variants in CYP2C9 affects the stability of anticoagulation in patients within the first 3 months following elective heart valve replacement. MATERIAL AND METHODS: In a case-control study we compared 18...
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