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Article

Effects of vitamin K epoxide reductase complex 1 gene polymorphisms on warfarin control in Japanese patients with left ventricular assist devices (LVAD).

European journal of clinical pharmacology - 1 Jul 2018

Nakagita Kazuki, Wada Kyoichi, Mukai Yutaro, Uno Takaya, Nishino Ryoji, Matsuda Sachi, Takenaka Hiromi, Terakawa Nobue, Oita Akira, Takada Mitsutaka

Abstract excerpt

PURPOSE: This study aimed to investigate relationships between times in therapeutic range (TTR) or warfarin sensitivity indexes (WSI) and VKORC1-1639G>A and CYP2C9 polymorphisms in patients with left ventricular assist devices (LVAD). METHODS: Severe heart failure patients who received LVAD from January 1, 2013 to October 31, 2017 were recruited. Relationships between TTR or WSI and VKORC1-1639G>A and CYP2C9 gene...

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Source

Identifiers

PMID: 29781049
DOI: 10.1007/s00228-018-2483-8

Genes

VKORC1
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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