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Article

The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.

Nucleic acids research - 19 Sept 2016

Herruzo Esther, Ontoso David, González-Arranz Sara, Cavero Santiago, Lechuga Ana, San-Segundo Pedro A

Abstract excerpt

Meiotic cells possess surveillance mechanisms that monitor critical events such as recombination and chromosome synapsis. Meiotic defects resulting from the absence of the synaptonemal complex component Zip1 activate a meiosis-specific checkpoint network resulting in delayed or arrested meiotic progression. Pch2 is an evolutionarily conserved AAA+ ATPase required for the checkpoint-induced meiotic block in the...

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Identifiers

PMID: 27257060
DOI: 10.1093/nar/gkw506
PMCID: PMC5027488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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