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Article

Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Chen Cheng, Jomaa Ahmad, Ortega Joaquin, Alani Eric E

Abstract excerpt

In budding yeast the pachytene checkpoint 2 (Pch2) protein regulates meiotic chromosome axis structure by maintaining the domain-like organization of the synaptonemal complex proteins homolog pairing 1 (Hop1) and molecular zipper 1 (Zip1). Pch2 has also been shown to modulate meiotic double-stran...

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PMID: 24367111
DOI: 10.1073/pnas.1310755111
PMCID: PMC3890899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24367111-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1.PMID 24367111Read ↗

The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.Semantic proximity Read ↗

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