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Article

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.

Molecular and cellular biology - 1 Mar 2011

Lai Yi-Ju, Lin Feng-Ming, Chuang Mei-Jen, Shen Hui-Ju, Wang Ting-Fang

Abstract excerpt

The synaptonemal complex (SC) is a meiosis-specific tripartite structure that forms between two homologous chromosomes; it consists of a central region and two parallel lateral elements. Lateral elements also are called axial elements prior to synapsis. In Saccharomyces cerevisiae, Red1, Hop1, and Mek1 are structural components of axial/lateral elements. The red1/mek1/hop1 mutants all exhibit reduced levels of...

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Identifiers

PMID: 21173162
DOI: 10.1128/MCB.00895-10
PMCID: PMC3067829

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Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.PMID 21173162Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

The yeast Red1 protein localizes to the cores of meiotic chromosomes.Semantic proximity Read ↗

Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.Semantic proximity Read ↗

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Semantic proximity Read ↗

Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.Semantic proximity Read ↗

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Semantic proximity Read ↗

Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.Semantic proximity Read ↗

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.Semantic proximity Read ↗

Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.Semantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

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