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Article

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.

The Journal of biological chemistry - 15 Jan 1999

de los Santos T, Hollingsworth N M

Abstract excerpt

The synaptonemal complex (SC) is a proteinaceous structure formed between pairs of homologous chromosomes during prophase I of meiosis. The proper assembly of axial elements (AEs), lateral components of the SC, during meiosis in the yeast, Saccharomyces cerevisiae, is essential for wild-type levels of recombination and for the accurate segregation of chromosomes at the first meiotic division. Genetic experiments...

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PMID: 9880561
DOI: 10.1074/jbc.274.3.1783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.PMID 9880561Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

The yeast Red1 protein localizes to the cores of meiotic chromosomes.Semantic proximity Read ↗

Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.Semantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.Semantic proximity Read ↗

Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.Semantic proximity Read ↗

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Semantic proximity Read ↗

The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.Semantic proximity Read ↗

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