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Article

PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.

PLoS genetics - 1 Jul 2020

Giacopazzi Stefani, Vong Daniel, Devigne Alice, Bhalla Needhi

Abstract excerpt

The conserved ATPase, PCH-2/TRIP13, is required during both the spindle checkpoint and meiotic prophase. However, its specific role in regulating meiotic homolog pairing, synapsis and recombination has been enigmatic. Here, we report that this enzyme is required to proofread meiotic homolog interactions. We generated a mutant version of PCH-2 in C. elegans that binds ATP but cannot hydrolyze it: pch-2E253Q. In...

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Identifiers

PMID: 32730253
DOI: 10.1371/journal.pgen.1008904
PMCID: PMC7433886

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