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Article

Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.

Molecular and cellular biology - 1 Jul 2000

Bailis J M, Smith A V, Roeder G S

Abstract excerpt

The Saccharomyces cerevisiae zip1 mutant, which exhibits defects in synaptonemal complex formation and meiotic recombination, triggers a checkpoint that causes cells to arrest at the pachytene stage of meiotic prophase. Overproduction of either the meiotic chromosomal protein Red1 or the meiotic kinase Mek1 bypasses this checkpoint, allowing zip1 cells to sporulate. Red1 or Mek1 overproduction also promotes...

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Identifiers

PMID: 10848609
DOI: 10.1128/MCB.20.13.4838-4848.2000
PMCID: PMC85935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.PMID 10848609Read ↗

A novel nonnull ZIP1 allele triggers meiotic arrest with synapsed chromosomes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.Semantic proximity Read ↗

Separation of roles of Zip1 in meiosis revealed in heterozygous mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Meiotic cells monitor the status of the interhomolog recombination complex.Semantic proximity Read ↗

The yeast Red1 protein localizes to the cores of meiotic chromosomes.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.Semantic proximity Read ↗

The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28.Semantic proximity Read ↗

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.Semantic proximity Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.Semantic proximity Read ↗

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