Article
The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.
Cell - 7 Aug 1998
Leu J Y, Chua P R, Roeder G S
Abstract excerpt
The hop2 mutant of S. cerevisiae displays a novel phenotype: meiotic chromosomes form nearly wild-type amounts of synaptonemal complex, but most chromosomes are engaged in synapsis with nonhomologous partners. The meiosis-specific Hop2 protein localizes to chromosomes prior to and during synapsis and in the absence of the double-strand breaks that initiate recombination. hop2 strains sustain a wild-type level of...
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