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Article

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.

Molecular and cellular biology - 1 Aug 2013

Cheng Yun-Hsin, Chuang Chi-Ning, Shen Hui-Ju, Lin Feng-Ming, Wang Ting-Fang

Abstract excerpt

Recombination and synapsis of homologous chromosomes are hallmarks of meiosis in many organisms. Meiotic recombination is initiated by Spo11-induced DNA double-strand breaks (DSBs), whereas chromosome synapsis is mediated by a tripartite structure named the synaptonemal complex (SC). Previously, we proposed that budding yeast SC is assembled via noncovalent interactions between the axial SC protein Red1, SUMO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23775120
DOI: 10.1128/MCB.00438-13
PMCID: PMC3753904

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.PMID 23775120Read ↗

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Semantic proximity Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination.Semantic proximity Read ↗

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Semantic proximity Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.Semantic proximity Read ↗

Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.Semantic proximity Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets.Semantic proximity Read ↗

A synaptonemal complex protein promotes homology-independent centromere coupling.Semantic proximity Read ↗

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