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Article

Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice.

Scientific reports - 3 Jun 2016

Zhang Jingjing, Bedel Romain, Krovi S Harsha, Tuttle Kathryn D, Zhang Bicheng, Gross James, Gapin Laurent, Matsuda Jennifer L

Abstract excerpt

Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα rearrangement between the Trav11 and Traj18 gene segments. When paired with certain Trbv TCRβ chains, these TCRs recognize lipid antigens presented by the major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 27256918
DOI: 10.1038/srep27375
PMCID: PMC4891675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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