Article
Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.
Frontiers in immunology - 1 Jan 2020
Papadogianni Georgia, Ravens Inga, Dittrich-Breiholz Oliver, Bernhardt Günter, Georgiev Hristo
Abstract excerpt
Invariant natural killer T (iNKT) cells represent a subclass of T cells possessing a restricted repertoire of T cell receptors enabling them to recognize lipid derived ligands. iNKT cells are continuously generated in thymus and differentiate into three main subpopulations: iNKT1, iNKT2, and iNKT17 cells. We investigated the transcriptomes of these subsets comparing cells isolated from young adult (6-10 weeks...
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