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Article

A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.

Scientific reports - 6 Oct 2017

Ren Yue, Sekine-Kondo Etsuko, Shibata Risa, Kato-Itoh Megumi, Umino Ayumi, Yanagida Ayaka, Satoh Masashi, Inoue Komaki, Yamaguchi Tomoyuki, Mochida Keiichi, Nakae Susumu, Van Kaer Luc, Iwabuchi Kazuya, Nakauchi Hiromitsu, Watarai Hiroshi

Abstract excerpt

iNKT cells play important roles in immune regulation by bridging the innate and acquired immune systems. The functions of iNKT cells have been investigated in mice lacking the Traj18 gene segment that were generated by traditional embryonic stem cell technology, but these animals contain a biased T cell receptor (TCR) repertoire that might affect immune responses. To circumvent this confounding factor, we have...

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Identifiers

PMID: 28986544
DOI: 10.1038/s41598-017-12475-4
PMCID: PMC5630609

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