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Article

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016

Fedeli Maya, Riba Michela, Garcia Manteiga Jose Manuel, Tian Lei, Viganò Valentina, Rossetti Grazisa, Pagani Massimiliano, Xiao Changchun, Liston Adrian, Stupka Elia, Cittaro Davide, Abrignani Sergio, Provero Paolo, Dellabona Paolo, Casorati Giulia

Abstract excerpt

Invariant natural killer T cells (iNKT) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic developmental program regulated by microRNAs (miRNAs). Deleting miRNAs by Dicer ablation (Dicer KO) in thymocytes selectively impairs iNKT cell survival and functional differentiation. To unravel this miRNA-dependent program, we systemically identified transcripts that were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27930306
DOI: 10.1073/pnas.1612024114
PMCID: PMC5187732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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