Article
Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell.
International immunology - 1 Oct 2014
Ren Yue, Dashtsoodol Nyambayar, Watarai Hiroshi, Koseki Haruhiko, Quan Chengshi, Taniguchi Masaru
Abstract excerpt
NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analysis. Here, two lines of induced pluripotent stem cell-derived mice (NKT-iPSC-derived mice) were...
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