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Article

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Nature structural & molecular biology - 20 Nov 2011

Moser Bettina A, Chang Ya-Ting, Kosti Jorgena, Nakamura Toru M

Abstract excerpt

The evolutionarily conserved shelterin complex has been shown to play both positive and negative roles in telomerase regulation in mammals and fission yeast. Although shelterin prevents the checkpoint kinases ATM and ATR from fully activating DNA damage responses at telomeres in mammalian cells, those kinases also promote telomere maintenance. In fission yeast, cells lacking both Tel1 (ATM ortholog) and Rad3 (ATR...

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Identifiers

PMID: 22101932
DOI: 10.1038/nsmb.2187
PMCID: PMC3230746

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.PMID 22101932Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase RecruitmentSemantic proximity Read ↗

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.Semantic proximity Read ↗

Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.Semantic proximity Read ↗

Fission yeast Ccq1 is a modulator of telomerase activity.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresSemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere MaintenanceSemantic proximity Read ↗

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read ↗

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The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.Semantic proximity Read ↗

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