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Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia.

Experimental hematology - 1 Oct 2016

Maruyama Hiroyuki, Katagiri Takamasa, Kashiwase Koichi, Shiina Takashi, Sato-Otsubo Aiko, Zaimoku Yoshitaka, Maruyama Kana, Hosokawa Kohei, Ishiyama Ken, Yamazaki Hirohito, Inoko Hidetoshi, Ogawa Seishi, Nakao Shinji

Abstract excerpt

To gain insight into the origin and clinical significance of leukocytes that lack human leukocyte antigen A (HLA-A) allele expression caused by a copy-number-neutral loss of heterozygosity in the short arm of chromosome 6 in patients with acquired aplastic anemia (AA), we used a high-sensitivity flow cytometry assay to investigate the presence of HLA-A allele-lacking leukocytes (HLA-LLs) in 144 AA patients....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27250585
DOI: 10.1016/j.exphem.2016.05.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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