Article
HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia.
Blood - 30 Dec 2021
Zaimoku Yoshitaka, Patel Bhavisha A, Adams Sharon D, Shalhoub Ruba, Groarke Emma M, Lee Audrey Ai Chin, Kajigaya Sachiko, Feng Xingmin, Rios Olga Julia, Eager Holly, Alemu Lemlem, Quinones Raffo Diego, Wu Colin O, Flegel Willy A, Young Neal S
Abstract excerpt
Immune aplastic anemia (AA) features somatic loss of HLA class I allele expression on bone marrow cells, consistent with a mechanism of escape from T-cell-mediated destruction of hematopoietic stem and progenitor cells. The clinical significance of HLA abnormalities has not been well characterized. We examined the somatic loss of HLA class I alleles and correlated HLA loss and mutation-associated HLA genotypes...
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