Clonal evolution and clinical significance of copy number neutral loss of heterozygosity of chromosome arm 6p in acquired aplastic anemia.

doi:10.1016/j.cancergen.2015.10.002

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Article

Clonal evolution and clinical significance of copy number neutral loss of heterozygosity of chromosome arm 6p in acquired aplastic anemia.

Cancer genetics - 1 Jan 2000

Betensky Marisol, Babushok Daria, Roth Jacquelyn J, Mason Philip J, Biegel Jaclyn A, Busse Tracy M, Li Yimei, Lind Curt, Papazoglou Anna, Monos Dimitri, Podsakoff Gregory, Bessler Monica, Olson Timothy S

Abstract excerpt

Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells. Factors predicting response to immune suppression therapy (IST) or development of myelodysplastic syndrome (MDS) are beginning to be elucidated. Our recent data suggest most patients with aAA treated with IST develop clonal somatic genetic alterations in hematopoietic cells. One frequent acquired...

Topics

Adolescent
Adult
Aged
Anemia, Aplastic
Child
Child, Preschool
Chromosomes, Human, Pair 6
Clonal Evolution
DNA Copy Number Variations
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Infant, Newborn

Loss of Heterozygosity

Male

Middle Aged

Polymorphism, Single Nucleotide

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26702937
DOI: 10.1016/j.cancergen.2015.10.002
PMCID: PMC4738084

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