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HLA Class I Allele Loss and Bone Marrow Transplantation Outcomes in Immune Aplastic Anemia.

Transplantation and cellular therapy - 1 Mar 2024

Zaimoku Yoshitaka, Katagiri Takamasa, Nakagawa Noriharu, Imi Tatsuya, Maruyama Hiroyuki, Takamatsu Hiroyuki, Ishiyama Ken, Yamazaki Hirohito, Miyamoto Toshihiro, Nakao Shinji

Abstract excerpt

In patients with immune-mediated acquired aplastic anemia (AA), HLA class I alleles often disappear from the surface of hematopoietic progenitor cells, potentially enabling evasion from cytotoxic T lymphocyte-mediated pathogenesis. Although HLA class I allele loss has been studied in AA patients treated with immunosuppressive therapy (IST), its impact on allogeneic bone marrow transplantation (BMT) has not been...

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PMID: 37972732
DOI: 10.1016/j.jtct.2023.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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