HLA Class I Allele Loss and Bone Marrow Transplantation Outcomes in Immune Aplastic Anemia.

doi:10.1016/j.jtct.2023.11.013

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Article

HLA Class I Allele Loss and Bone Marrow Transplantation Outcomes in Immune Aplastic Anemia.

Transplantation and cellular therapy - 1 Mar 2024

Zaimoku Yoshitaka, Katagiri Takamasa, Nakagawa Noriharu, Imi Tatsuya, Maruyama Hiroyuki, Takamatsu Hiroyuki, Ishiyama Ken, Yamazaki Hirohito, Miyamoto Toshihiro, Nakao Shinji

Abstract excerpt

In patients with immune-mediated acquired aplastic anemia (AA), HLA class I alleles often disappear from the surface of hematopoietic progenitor cells, potentially enabling evasion from cytotoxic T lymphocyte-mediated pathogenesis. Although HLA class I allele loss has been studied in AA patients treated with immunosuppressive therapy (IST), its impact on allogeneic bone marrow transplantation (BMT) has not been...

Topics

Humans
Bone Marrow Transplantation
Anemia, Aplastic
Alleles
HLA-B Antigens
Unrelated Donors
HLA-A Antigens

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Open in PubMed

Identifiers

PMID: 37972732
DOI: 10.1016/j.jtct.2023.11.013

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