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Article

Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

Blood - 15 Dec 2011

Katagiri Takamasa, Sato-Otsubo Aiko, Kashiwase Koichi, Morishima Satoko, Sato Yusuke, Mori Yuka, Kato Motohiro, Sanada Masashi, Morishima Yasuo, Hosokawa Kohei, Sasaki Yumi, Ohtake Shigeki, Ogawa Seishi, Nakao Shinji

Abstract excerpt

Idiopathic aplastic anemia (AA) is a common cause of acquired BM failure. Although autoimmunity to hematopoietic progenitors is thought to be responsible for its pathogenesis, little is known about the molecular basis of this autoimmunity. Here we show that a substantial proportion of AA patients harbor clonal hematopoiesis characterized by the presence of acquired copy number-neutral loss of heterozygosity...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Anemia, Aplastic
Child
Child, Preschool
Chromosomes, Human, Pair 6
DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Frequency

HLA Antigens

HLA-B Antigens

Haplotypes

Hematopoietic Stem Cells

Humans

Infant

Source

Identifiers

PMID: 21963603
DOI: 10.1182/blood-2011-07-365189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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