Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Clinical significance of detecting human leukocyte antigen class I allele-lacking leukocytes in aplastic anemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2022

Hosokawa Kohei, Nakao Shinji

Abstract excerpt

Human leukocyte antigen (HLA) class I allele-lacking [HLA (-)] leukocytes provide compelling evidence that cytotoxic T-lymphocytes are involved in the development of aplastic anemia (AA). However, the clinical significance and precise mechanisms underlying clonal hematopoiesis by HLA (-) hematopoietic stem progenitor cells remain unknown. In HLA (-) cells from patients with AA, we discovered a common nonsense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Anemia, Aplastic
Share to Hemoglobinuria, Paroxysmal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA Antigens

Source

Identifiers

PMID: 36058861
DOI: 10.11406/rinketsu.63.899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Clinical significance of detecting human leukocyte antigen class I allele-lacking leukocytes in aplastic anemia].PMID 36058861Read ↗

[A loss-of-function mutation in exon1 of limited HLA class I alleles is common in patients with aplastic anemia].Semantic proximity Read ↗

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.Semantic proximity Read ↗

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia.Semantic proximity Read ↗

[Somatic Mutations of Acquired Aplastic Anemia].Semantic proximity Read ↗

[Acquired aplastic anemia: recent advances in pathophysiology and treatment].Semantic proximity Read ↗

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemiaSemantic proximity Read ↗

Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia.Semantic proximity Read ↗

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.Semantic proximity Read ↗

Current Concepts of the Pathogenesis of Aplastic AnemiaSemantic proximity Read ↗

HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

[Molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglobinuria: a role of NKG2D-medicated immunity].Semantic proximity Read ↗

Association between human leukocyte antigen and immunosuppressive treatment outcomes in Chinese patients with aplastic anemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.