Loss-Prone HLA Class I Alleles Inform Outcomes of Early Hematopoietic Cell Transplantation in Acquired Aplastic Anemia.

doi:10.1002/ajh.70054

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Article

Loss-Prone HLA Class I Alleles Inform Outcomes of Early Hematopoietic Cell Transplantation in Acquired Aplastic Anemia.

American journal of hematology - 1 Dec 2025

Zaimoku Yoshitaka, Yamazaki Hirohito, Kanaya Minoru, Hiramoto Nobuhiro, Ishiyama Ken, Takenaka Katsuto, Murata Makoto, Uchida Naoyuki, Doki Noriko, Yamamoto Ryusuke, Nishida Testuya, Onodera Koichi, Machida Shinichiro, Kanda Yoshinobu, Eto Tetsuya, Kataoka Keisuke, Asada Noboru, Itagaki Mitsuhiro, Sakata-Yanagimoto Mamiko, Ishimaru Fumihiko, Onizuka Makoto, Ichinohe Tatsuo, Atsuta Yoshiko, Onishi Yasushi

Abstract excerpt

HLA class I allele loss in acquired aplastic anemia (AA) represents an immune escape from the T cell-mediated pathogenesis. We investigated the impact of loss-prone HLA alleles on the hematopoietic cell transplantation (HCT) outcomes using registry data of 875 Japanese patients with acquired AA. HLA associations were evident exclusively among 399 patients who received HCT within 1 year of the diagnosis,...

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PMID: 40910546
DOI: 10.1002/ajh.70054

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