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Article

CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking.

Scientific reports - 2 Jun 2016

Weng Pei-Hsuan, Chen Jen-Hau, Chen Ta-Fu, Sun Yu, Wen Li-Li, Yip Ping-Keung, Chu Yi-Min, Chen Yen-Ching

Abstract excerpt

α7 nicotinic acetylcholine receptor (α7nAChR, encoded by CHRNA7) is involved in dementia pathogenesis through cholinergic neurotransmission, neuroprotection and interactions with amyloid-β. Smoking promotes atherosclerosis and increases dementia risk, but nicotine exerts neuroprotective effect via α7nAChR in preclinical studies. No studies explored the gene-gene, gene-environment interactions between CHRNA7...

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Source

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Identifiers

PMID: 27249957
DOI: 10.1038/srep27231
PMCID: PMC4890170

Genes

CHRNA7
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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