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Article

Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease.

American journal of Alzheimer's disease and other dementias - 1 Mar 2015

Braga Ianna Lacerda Sampaio, Silva Patricia Natalia, Furuya Tatiane Katsue, Santos Leonardo Caires, Pires Belisa Caldana, Mazzotti Diego Robles, Bertolucci Paulo Henrique, Cendoroglo Maysa Seabra, Smith Marília Cardoso

Abstract excerpt

The loss of cholinergic transmission is considered to be an important cause of Alzheimer's disease (AD). Treatment with acetyl cholinesterase inhibitors (ChEIs) shows benefits; however, great heterogeneity has been observed in patient responses. We evaluated apolipoprotein E (APOE) and α7 nicotinic receptor (CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to...

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Identifiers

PMID: 24951635
DOI: 10.1177/1533317514539540
PMCID: PMC10852661

Genes

CHRNA7
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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