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Article

Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.

Current drug targets - 1 Jan 2017

Russo Patrizia, Kisialiou Aliaksei, Moroni Rossana, Prinzi Giulia, Fini Massimo

Abstract excerpt

BACKGROUND: Cholinergic transmission loss is one of the major features in Alzheimer&#039;s Disease (AD). Acetylcholinesterase inhibitors (AChEI) are moderately active in AD. α7nAChR (alpha-7 nicotinic acetylcholine receptor), encoded by CHRNA7 (Nicotinic Cholinergic Receptor Alpha-7 gene), is involved in the cholinergic neurotransmission and AD pathogenesis. α7nAChR is a putative receptor of amyloid beta...

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Identifiers

PMID: 26424395
DOI: 10.2174/1389450116666151001111826

Genes

CHRNA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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