Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.

Current drug targets - 1 May 2012

Neri Monica, Bonassi Stefano, Russo Patrizia

Abstract excerpt

The presence of memory impairment and cognitive deficits in the Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Pick's disease (PiD) has been associated to dysfunction of cholinergic transmission, possibly due to the loss of cholinergic neurons and to the elimination of nAChR in de...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha7 Nicotinic Acetylcholine Receptor
Share to Alzheimer Disease
Share to Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Polymorphism, Genetic

Share to Receptors, Nicotinic

Source

Identifiers

PMID: 22300029
DOI: 10.2174/138945012800398928

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22300029-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.PMID 22300029Read ↗

Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia.Semantic proximity Read ↗

Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.Semantic proximity Read ↗

CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking.Semantic proximity Read ↗

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.Semantic proximity Read ↗

Complement C7is a novel risk gene for Alzheimer's disease in Han ChineseSemantic proximity Read ↗

CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease.Semantic proximity Read ↗

Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A.Semantic proximity Read ↗

CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer's Disease Patients.Semantic proximity Read ↗

Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease.Semantic proximity Read ↗

Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitabilitySemantic proximity Read ↗

Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

The nACHR4 594C/T polymorphism in Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.