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Article

CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer's Disease Patients.

Journal of Alzheimer's disease : JAD - 16 Apr 2016

Clarelli Ferdinando, Mascia Elisabetta, Santangelo Roberto, Mazzeo Salvatore, Giacalone Giacomo, Galimberti Daniela, Fusco Federica, Zuffi Marta, Fenoglio Chiara, Franceschi Massimo, Scarpini Elio, Forloni Gianluigi, Magnani Giuseppe, Comi Giancarlo, Albani Diego, Martinelli Boneschi Filippo

Abstract excerpt

Previous studies suggest that genetic variants in CHRNA7, which encodes for the major subunit of the acetylcholine receptor (α7-nAChR), are associated with the clinical response to cholinesterase inhibitors (ChEI) in Alzheimer's disease (AD) patients. We sought to replicate the association of two SNPs in the CHRNA7 gene, rs6494223 and rs8024987, with response to ChEI treatment in an Italian cohort of 169 AD...

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Source

Identifiers

PMID: 27104904
DOI: 10.3233/JAD-160074

Genes

CHRNA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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