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Article

APOBEC4 Enhances the Replication of HIV-1

1 Jun 2016

Abstract excerpt

APOBEC4 (A4) is a member of the AID/APOBEC family of cytidine deaminases. In this study we found a high mRNA expression of A4 in human testis. In contrast, there were only low levels of A4 mRNA detectable in 293T, HeLa, Jurkat or A3.01 cells. Ectopic expression of A4 in HeLa cells resulted in mostly cytoplasmic localization of the protein. To test whether A4 has antiviral activity similar to that of proteins of...

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PMID: 27249646
DOI: 10.1371/journal.pone.0155422

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