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APOBEC3G and APOBEC3F Require an Endogenous Cofactor to Block HIV-1 Replication

3 Jul 2008

Abstract excerpt

APOBEC3G (A3G)/APOBEC3F (A3F) are two members of APOBEC3 cytidine deaminase subfamily. Although they potently inhibit the replication of vif-deficient HIV-1, this mechanism is still poorly understood. Initially, A3G/A3F were thought to catalyze C-to-U transitions on the minus-strand viral cDNAs during reverse transcription to disrupt the viral life cycle. Recently, it was found more likely that A3G/A3F directly...

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PMID: 18604271
DOI: 10.1371/journal.ppat.1000095

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