Article
APOBEC3G inhibits elongation of HIV-1 reverse transcripts.
PLoS pathogens - 1 Dec 2008
Bishop Kate N, Verma Mohit, Kim Eun-Young, Wolinsky Steven M, Malim Michael H
Abstract excerpt
APOBEC3G (A3G) is a host cytidine deaminase that, in the absence of Vif, restricts HIV-1 replication and reduces the amount of viral DNA that accumulates in cells. Initial studies determined that A3G induces extensive mutation of nascent HIV-1 cDNA during reverse transcription. It has been proposed that this triggers the degradation of the viral DNA, but there is now mounting evidence that this mechanism may not...
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