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T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity

18 Sept 2007

Abstract excerpt

The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell lines, A3G induces catastrophic hypermutation by deaminating the HIV-1 genome. Interestingly, studies suggest that endogenous A3G in T cells induces less hypermutation than would be expected. However, to date, the specific deaminase activity of endogenous A3G...

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PMID: 17892323
DOI: 10.1371/journal.ppat.0030135

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