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Stably Expressed APOBEC3F Has Negligible Antiviral Activity

12 Aug 2010

Abstract excerpt

APOBEC3F (A3F) is a member of the family of cytidine deaminases that is often coexpressed with APOBEC3G (A3G) in cells susceptible to HIV infection. A3F has been shown to have strong antiviral activity in transient-expression studies, and together with A3G, it is considered the most potent cytidine deaminase targeting HIV. Previous analyses suggested that the antiviral properties of A3F can be dissociated from...

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PMID: 20702622
DOI: 10.1128/jvi.01249-10

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