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Restriction of Porcine Endogenous Retrovirus by Porcine APOBEC3 Cytidine Deaminases

10 Feb 2011

Abstract excerpt

Xenotransplantation of porcine cells, tissues, and organs shows promise to surmount the shortage of human donor materials. Among the barriers to pig-to-human xenotransplantation are porcine endogenous retroviruses (PERV) since functional representatives of the two polytropic classes, PERV-A and PERV-B, are able to infect human embryonic kidney cells in vitro, suggesting that a xenozoonosis in vivo could occur. To...

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PMID: 21307203
DOI: 10.1128/jvi.01880-10

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