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Article

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice

22 Jan 2015

Abstract excerpt

Ageing is a complex biological process for which underlying biochemical changes are still largely unknown. We performed comparative profiling of the cellular proteome and metabolome to understand the molecular basis of ageing in Caspase-2-deficient (Casp2(-/-)) mice that are a model of premature ageing in the absence of overt disease. Age-related changes were determined in the liver and serum of young (6-9 week)...

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PMID: 25611376
DOI: 10.1038/cddis.2014.567

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