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Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging

8 Dec 2023

Abstract excerpt

Skeletal muscle aging is characterized by the loss of muscle mass, strength and function, mainly attributed to the atrophy of glycolytic fibers. Underlying mechanisms driving the skeletal muscle functional impairment are yet to be elucidated. To unbiasedly uncover its molecular mechanisms, we recurred to gene expression and metabolite profiling in a glycolytic muscle, Extensor digitorum longus (EDL), from young...

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PMID: 38066057
DOI: 10.1038/s42003-023-05595-3

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