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Article

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.

Aging cell - 1 Jun 2016

Noren Hooten Nicole, Martin-Montalvo Alejandro, Dluzen Douglas F, Zhang Yongqing, Bernier Michel, Zonderman Alan B, Becker Kevin G, Gorospe Myriam, de Cabo Rafael, Evans Michele K

Abstract excerpt

Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age-related chronic disease. However, the molecular mechanisms underlying this phenotype are unknown. Here, we show that metformin treatment increases the levels of the microRNA-processing protein DICER1 in mice...

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Source

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Identifiers

PMID: 26990999
DOI: 10.1111/acel.12469
PMCID: PMC4854919

Genes

DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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