Article
Landscape of tumor-infiltrating T cell repertoire of human cancers.
Nature genetics - 1 Jul 2016
Li Bo, Li Taiwen, Pignon Jean-Christophe, Wang Binbin, Wang Jinzeng, Shukla Sachet A, Dou Ruoxu, Chen Qianming, Hodi F Stephen, Choueiri Toni K, Wu Catherine, Hacohen Nir, Signoretti Sabina, Liu Jun S, Liu X Shirley
Abstract excerpt
We developed a computational method to infer the complementarity-determining region 3 (CDR3) sequences of tumor-infiltrating T cells in 9,142 RNA-seq samples across 29 cancer types. We identified over 600,000 CDR3 sequences, including 15% that were full length. CDR3 sequence length distribution and amino acid conservation, as well as variable gene usage, for infiltrating T cells in many tumors, except in brain...
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