Article
Bioinformatics for Cancer Immunotherapy.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Holtsträter Christoph, Schrörs Barbara, Bukur Thomas, Löwer Martin
Abstract excerpt
Our immune system plays a key role in health and disease as it is capable of responding to foreign antigens as well as acquired antigens from cancer cells. Latter are caused by somatic mutations, the so-called neoepitopes, and might be recognized by T cells if they are presented by HLA molecules on the surface of cancer cells. Personalized mutanome vaccines are a class of customized immunotherapies, which is...
Topics
- Animals
- Cancer Vaccines
- Computational Biology
- Humans
- Immunotherapy
- Mutation
- Neoplasms
- T-Lymphocytes