Article
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival.
Genome research - 1 May 2014
Brown Scott D, Warren Rene L, Gibb Ewan A, Martin Spencer D, Spinelli John J, Nelson Brad H, Holt Robert A
Abstract excerpt
Somatic missense mutations can initiate tumorogenesis and, conversely, anti-tumor cytotoxic T cell (CTL) responses. Tumor genome analysis has revealed extreme heterogeneity among tumor missense mutation profiles, but their relevance to tumor immunology and patient outcomes has awaited comprehensive evaluation. Here, for 515 patients from six tumor sites, we used RNA-seq data from The Cancer Genome Atlas to...
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