Article
Comprehensive analysis of neoantigens derived from structural variation across whole genomes from 2528 tumors.
Genome biology - 17 Jul 2023
Shi Yang, Jing Biyang, Xi Ruibin
Abstract excerpt
BACKGROUND: Neoantigens are critical for anti-tumor immunity and have been long-envisioned as promising therapeutic targets. However, current neoantigen analyses mostly focus on single nucleotide variations (SNVs) and indel mutations and seldom consider structural variations (SVs) that are also prevalent in cancer. RESULTS: Here, we develop a computational method termed NeoSV, which incorporates SV annotation,...
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