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Article

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies.

Nature communications - 8 Feb 2019

Henderson Rory, Watts Brian E, Ergin Hieu N, Anasti Kara, Parks Robert, Xia Shi-Mao, Trama Ashley, Liao Hua-Xin, Saunders Kevin O, Bonsignori Mattia, Wiehe Kevin, Haynes Barton F, Alam S Munir

Abstract excerpt

Somatic mutations within antibody variable and framework regions (FWR) can alter thermostability and structural flexibility, but their impact on functional potency is unclear. Here we study thermostability and use molecular dynamics (MD) simulations to assess the role of FWR mutations during maturation of HIV-1 broadly neutralizing antibodies (bnAbs). The tested bnAbs show lower thermostability than their...

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Share to Antibodies, Neutralizing
Share to Calorimetry, Differential Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30737386
DOI: 10.1038/s41467-019-08415-7
PMCID: PMC6368608

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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