Article
Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
The Journal of experimental medicine - 3 Jun 2013
Diskin Ron, Klein Florian, Horwitz Joshua A, Halper-Stromberg Ariel, Sather D Noah, Marcovecchio Paola M, Lee Terri, West Anthony P, Gao Han, Seaman Michael S, Stamatatos Leonidas, Nussenzweig Michel C, Bjorkman Pamela J
Abstract excerpt
Recently identified broadly neutralizing antibodies (bNAbs) that potently neutralize most HIV-1 strains are key to potential antibody-based therapeutic approaches to combat HIV/AIDS in the absence of an effective vaccine. Increasing bNAb potencies and resistance to common routes of HIV-1 escape through mutation would facilitate their use as therapeutics. We previously used structure-based design to create the...
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